Research maps for complex topics
Turn scattered research into a shared topic map.
Thematic helps teams build shared maps of a topic, connect causes and effects, and turn source material into a focused research workspace.
Cause and effect graph
Huntington's Disease
Center node
Mutant Huntingtin Protein
The anchor of this map (entity). Its strongest causes and effects fan out around it.
Causal relationship
Antisense Oligonucleotide → Mutant Huntingtin Protein
ASOs lower mutant huntingtin expression in Huntington mouse models
Causal relationship
Htt Gene Mutation → Mutant Huntingtin Protein
Inherited CAG repeat expansion in HTT gene drives production of toxic mutant huntingtin protein
Causal relationship
Sky 0515 → Mutant Huntingtin Protein
dose-dependent knockdown of mutant huntingtin protein observed in Phase 1 clinical update
Causal relationship
Votoplam → Mutant Huntingtin Protein
Votoplam (PTC518) is an oral small-molecule splicing modifier that forces a premature stop into HTT mRNA, degrading the transcript and lowering huntingtin protein; PIVOT-HD showed dose-dependent lowering (23% low / 36% high dose at 1 year)
Causal relationship
Branaplam → Mutant Huntingtin Protein
Oral drug branaplam lowered huntingtin levels in HD patients.
Mutant Huntingtin Protein
Where the map converges: 5 causes feed in.
Evidence
0.44Inherited CAG repeat expansion in HTT gene drives production of toxic mutant huntingtin protein
Source: strongest evidenced cause link
Node detail
strength 44Antisense Oligonucleotide
Best path: Antisense Oligonucleotide → Mutant Huntingtin Protein
Tour tips
FinaleMake any node the center to re-orient the map, then use discover more to grow the promising branches.
Center orientation
Lineage fans out from the selected center.
- Ingest
- Sources
- Resolve
- Signals
- Share
- Maps