Thematic Pro

Research maps for complex topics

Turn scattered research into a shared topic map.

Thematic Pro helps teams build shared maps of a topic, connect causes and effects, and turn source material into a focused research workspace.

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Huntington's Disease map

Cause and effect graph

Huntington's Disease

Build complete 1-level preview
Center Mutant Huntingtin Protein
Cause Htt Gene Mutation
Cause Antisense Oligonucleotide
Cause Htt Lowering Therapy
Cause Allele Specific Crispr Cas9
Cause Sky 0515

Center node

Mutant Huntingtin Protein

The anchor of this map (entity). Its strongest causes and effects fan out around it.

Causal relationship

Htt Gene Mutation → Mutant Huntingtin Protein

Inherited CAG repeat expansion in HTT gene drives production of toxic mutant huntingtin protein

Reinforcing (+) 0.80

Causal relationship

Antisense Oligonucleotide → Mutant Huntingtin Protein

ASOs lower mutant huntingtin expression in Huntington mouse models

Opposing (-) 0.80

Causal relationship

Htt Lowering Therapy → Mutant Huntingtin Protein

therapies aimed at lowering mutant huntingtin levels reduce the toxic protein driving neurodegeneration

Opposing (-) 0.61

Causal relationship

Allele Specific Crispr Cas9 → Mutant Huntingtin Protein

Dual gRNAs targeting PAM-altering SNPs on mutant chromosome excise ~44 kb including promoter and CAG expansion, blocking mutant HTT mRNA and protein production

Opposing (-) 0.45

Causal relationship

Sky 0515 → Mutant Huntingtin Protein

dose-dependent knockdown of mutant huntingtin protein observed in Phase 1 clinical update

Opposing (-) 0.43

Mutant Huntingtin Protein

Where the map converges: 5 causes feed in.

Evidence

0.80

ASOs lower mutant huntingtin expression in Huntington mouse models

Source: strongest evidenced cause link

Node detail

strength 80

Htt Gene Mutation

Best path: Htt Gene Mutation → Mutant Huntingtin Protein

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Tour tips

Finale

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Lineage fans out from the selected center.

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  • 8 published maps
  • 381 cited sources
  • 459 claims

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