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Neuropsychobiology

Circadian and Sleep-Related Polygenic Scores in Relation to Lithium Treatment Response in Bipolar Disorder

Neuropsychobiology, 2026 · Cited by 0 papers · doi:10.1159/000551565

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What this article backs

• Evening Chronotype ↔ Bipolar Disorder
• Lithium Treatment ↓ Circadian Rhythm Disruption

• Evening Chronotype correlates with Bipolar Disorder.
• Lithium Treatment decreases Circadian Rhythm Disruption.

In its own words

Patients with bipolar disorder (BD) frequently exhibit disrupted sleep patterns and a tendency for evening chronotype.

Lithium (Li), the first-line therapy for BD, stabilizes circadian rhythms and promotes morningness in responders (Rp).