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Nature

Comparative effectiveness of treatment strategies for bipolar disorder during and after lithium treatment - Nature Mental Health

Nature Mental Health, 2026 · Cited by 0 papers · doi:10.1038/s44220-026-00645-1

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What this article backs

• Lithium Treatment ↓ Relapse Rate

• Lithium Treatment decreases Relapse Rate.

In its own words

Comparative effectiveness of treatment strategies for bipolar disorder during and after lithium treatment

Corroborated by

• Illustration B

  Canadian Network for Mood and Anxiety Treatments ( CANMAT ) and International Society for Bipolar Disorders ( ISBD ) 2018 guidelines for the management of patients with bipolar disorder

  Bipolar Disorders · Mar 1, 2018 High trust

  Backs 6 claims

  • Lithium Treatment ↓ Manic Episode
  • Lithium Treatment ↓ Depressive Episode
  • Antipsychotic Treatment ↓ Manic Episode
  • Antipsychotic Treatment ↓ Depressive Episode
  • Antipsychotic Treatment ↓ Relapse Rate
  • Lithium Treatment ↓ Relapse Rate

  Read article →
• Illustration A

  Long-Term Lithium Therapy for Bipolar Disorder: Systematic Review and Meta-Analysis of Randomized Controlled Trials

  American Journal of Psychiatry · Jan 30, 2004 High trust

  Backs 3 claims

  • Lithium Treatment ↓ Relapse Rate
  • Lithium Treatment ✕ Manic Episode
  • Lithium Treatment ↓ Depressive Episode

  Read article →
• Illustration T

  A Placebo-Controlled 18-Month Trial of Lamotrigine and Lithium Maintenance Treatment in Recently Depressed Patients With Bipolar I Disorder

  The Journal of Clinical Psychiatry · Sep 15, 2003 High trust

  Backs 4 claims

  • Lamotrigine Treatment ↓ Relapse Rate
  • Lithium Treatment ↓ Relapse Rate
  • Lamotrigine Treatment ✕ Depressive Episode
  • Lithium Treatment ✕ Manic Episode

  Read article →
• Illustration A

  A Placebo-Controlled 18-Month Trial of Lamotrigine and Lithium Maintenance Treatment in Recently Manic or Hypomanic Patients With Bipolar I Disorder

  Archives of General Psychiatry · Apr 1, 2003 High trust

  Backs 4 claims

  • Lithium Treatment ↓ Relapse Rate
  • Lamotrigine Treatment ↓ Relapse Rate
  • Lamotrigine Treatment ✕ Depressive Episode
  • Lithium Treatment ✕ Manic Episode

  Read article →
• Illustration A

  A Randomized, Placebo-Controlled 12-Month Trial of Divalproex and Lithium in Treatment of Outpatients With Bipolar I Disorder

  Archives of General Psychiatry · May 1, 2000 High trust

  Backs 4 claims

  • Lithium Treatment ↓ Relapse Rate
  • Divalproex Treatment ↓ Depressive Episode
  • Divalproex Treatment ↓ Residual Depressive Symptoms
  • Divalproex Treatment ↓ Functional Impairment

  Read article →

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  Backs 1 claim

  • Multimodal Eeg Fnirs Classification ✕ Misdiagnosis

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  Disturbances of paraventricular thalamic nucleus neurons in bipolar disorder revealed by single-nucleus analysis - Nature Communications

  Nature · Jan 7, 2026 Standard

  Backs 1 claim

  • Paraventricular Thalamic Nucleus Disturbance ↔ Manic Episode

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  Circulating inflammatory proteins associated with risks of schizophrenia, bipolar disorder, and major depressive disorder: a mendelian randomization study - Translational Psychiatry

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  Backs 2 claims

  • Neuroinflammation ↑ Manic Episode
  • Neuroinflammation ↑ Depressive Episode

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  Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery - Nature Neuroscience

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  Backs 1 claim

  • Genetic Predisposition ↑ Manic Episode

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  Unraveling spatiotemporal dynamics in transdiagnosis subtypes of major depressive disorder and bipolar disorder: insights from co-activation patterns and treatment response - Molecular Psychiatry

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