Causal claim

Lithium Treatment Relapse Rate

Lithium Treatment decreases Relapse Rate.

They pull in opposite directions: more cause, less effect. The map scores it at 79% confidence, weighed from 6 articles.

DecreasesRelation
-Polarity
79%Confidence
unknownLag
UnspecifiedStrength
ActiveStatus

How it works

Lithium maintenance therapy reduces recurrence of mood episodes in bipolar disorder patients.

The evidence

6Backing articles
5Publishers
6Evidence records
May 2000–Apr 2026Coverage

Comparative effectiveness of treatment strategies for bipolar disorder during and after lithium treatment - Nature Mental Health

Nature Apr 23, 2026 Standard
Backs 1 claim
- Lithium Treatment Relapse Rate
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Canadian Network for Mood and Anxiety Treatments ( CANMAT ) and International Society for Bipolar Disorders ( ISBD ) 2018 guidelines for the management of patients with bipolar disorder

Bipolar Disorders Mar 1, 2018 High trust
Backs 6 claims
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Long-Term Lithium Therapy for Bipolar Disorder: Systematic Review and Meta-Analysis of Randomized Controlled Trials

American Journal of Psychiatry Jan 30, 2004 High trust
Backs 3 claims
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A Placebo-Controlled 18-Month Trial of Lamotrigine and Lithium Maintenance Treatment in Recently Depressed Patients With Bipolar I Disorder

The Journal of Clinical Psychiatry Sep 15, 2003 High trust
Backs 4 claims
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A Placebo-Controlled 18-Month Trial of Lamotrigine and Lithium Maintenance Treatment in Recently Manic or Hypomanic Patients With Bipolar I Disorder

Archives of General Psychiatry Apr 1, 2003 High trust
Backs 4 claims
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A Randomized, Placebo-Controlled 12-Month Trial of Divalproex and Lithium in Treatment of Outpatients With Bipolar I Disorder

Archives of General Psychiatry May 1, 2000 High trust
Backs 4 claims
Read article →

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