Thematic Pro

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Journal of Affective Disorders

Establishing Triple Chronotherapy as a fast-acting add-on treatment for unipolar and bipolar depression: evidence from an open-label randomized controlled trial in a real-world inpatient setting

Journal of Affective Disorders, 2025 · Cited by 1 paper · doi:10.1016/j.jad.2025.120537

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What this article backs

• Bright Light Therapy ↓ Depressive Episode
• Bright Light Therapy ↓ Suicide Risk

• Bright Light Therapy decreases Depressive Episode.
• Bright Light Therapy decreases Suicide Risk.

In its own words

Compared with TAU, add-on TCT produced greater and more rapid reductions in depression scores by day 5 that persisted through day 12 and at discharge.

Suicidality also decreased to a greater extent in the TCT group.

Corroborated by

• T

  Bright Light Therapy in the Morning or Midday for the Treatment of Nonseasonal Depression in Bipolar Disorder (LuBi): A Dose-Escalation Phase 1/2 Randomized Double-Blind Trial

  The Journal of Clinical Psychiatry · Jun 23, 2025 High trust

  Backs 1 claim

  • Bright Light Therapy ↓ Depressive Episode

  Read article →

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• Illustration J

  The efficacy of lumateperone across symptoms of a major depressive episode with mixed features in patients with major depressive disorder and bipolar disorder: Post hoc analyses

  Journal of Affective Disorders · Feb 23, 2026 High trust

  Backs 3 claims

  • Depressive Episode ✚ Residual Depressive Symptoms
  • Residual Depressive Symptoms ↑ Functional Impairment
  • Residual Depressive Symptoms ↑ Relapse Rate

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