Causal claim

Gene Therapy Neuroinflammation

Gene Therapy triggers Neuroinflammation.

The two move together: more cause, more effect. The map scores it at 0% confidence, weighed from 1 article.

TriggersRelation
+Polarity
0%Confidence
unknownLag
UnspecifiedStrength
DecayedStatus

How it works

Large doses of systemically administered AAV stimulate host immune responses, generating anti-capsid and anti-transgene immunity

The evidence

1Backing articles
1Publishers
1Evidence records
Feb 2020–Feb 2020Coverage

Management of Neuroinflammatory Responses to AAV-Mediated Gene Therapies for Neurodegenerative Diseases

Brain Sciences Feb 22, 2020 High trust
Backs 5 claims
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Where it sits

What feeds it

Fda Regulatory U Turn enables Gene Therapy.

What it drives

Neuroinflammation decreases Transgene Expression.

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