Causal claim
Circadian Gene Variants Circadian Rhythm DisruptionCircadian Gene Variants enables Circadian Rhythm Disruption.
The two move together: more cause, more effect. The map scores it at 49% confidence, weighed from 2 articles.
- EnablesRelation
- +Polarity
- 49%Confidence
- unknownLag
- UnspecifiedStrength
- ActiveStatus
How it works
Variants in core clock genes (CLOCK, BMAL1/ARNTL) weaken the transcriptional loop that keeps behavioural and hormonal rhythms entrained, predisposing to the circadian dysregulation seen in bipolar disorder.
The evidence
Where it sits
What feeds it
Nothing upstream on the map yet.