Causal claim

Circadian Rhythm Disruption Depressive Episode

Circadian Rhythm Disruption triggers Depressive Episode.

The two move together: more cause, more effect. The map scores it at 58% confidence, weighed from 3 articles.

TriggersRelation
+Polarity
58%Confidence
unknownLag
UnspecifiedStrength
ActiveStatus

How it works

A second brain clock rhythm, working in tandem with the sleep-wake cycle, drives alternation between mania and depression

The evidence

3Backing articles
3Publishers
3Evidence records
Jun 2016–Jul 2025Coverage

Metabolic plasticity: an evolutionary perspective on metabolic and circadian dysregulation in bipolar disorder - Molecular Psychiatry

Molecular Psychiatry Jul 19, 2025 High trust
Backs 3 claims
Read article →
What drives mood swings in bipolar disorder? Study points to a second brain clock

ScienceDaily Jan 27, 2025 Standard
Backs 2 claims
- Circadian Rhythm Disruption Manic Episode
- Circadian Rhythm Disruption Depressive Episode
Read article →
The role of sleep in bipolar disorder | NSS | Dove Medical Press

Nature and Science of Sleep Jun 1, 2016 High trust
Backs 2 claims
- Circadian Rhythm Disruption Depressive Episode
- Circadian Rhythm Disruption Manic Episode
Read article →

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Where it sits

What feeds it

What it drives

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