Thematic Pro

Causal claim

Htt Gene Mutation ⚡ Neuronal Intranuclear Inclusions

Htt Gene Mutation triggers Neuronal Intranuclear Inclusions.

The two move together: more cause, more effect. The map scores it at 0% confidence, weighed from 1 article.

• TriggersRelation
• +Polarity
• 0%Confidence
• unknownLag
• StrongStrength
• DecayedStatus

How it works

CAG/polyglutamine-repeat expansion in exon 1 of HD gene leads to formation of intranuclear inclusions containing huntingtin and ubiquitin in neurons

The evidence

• 1Backing articles
• 1Publishers
• 1Evidence records
• Aug 1997–Aug 1997Coverage

• Illustration C

  Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

  Cell · Aug 1, 1997 High trust

  Backs 3 claims

  • Htt Gene Mutation ⚡ Neuronal Intranuclear Inclusions
  • Neuronal Intranuclear Inclusions ⚡ Neurodegeneration
  • Mutant Huntingtin Protein Aggregates ✚ Neuronal Intranuclear Inclusions

  Read article →

Where it sits

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