Thematic Pro

Causal claim

Allele Specific Crispr Cas9 ✚ Htt Lowering Therapy

Allele Specific Crispr Cas9 enables Htt Lowering Therapy.

The two move together: more cause, more effect. The map scores it at 44% confidence, weighed from 1 article.

• EnablesRelation
• +Polarity
• 44%Confidence
• unknownLag
• StrongStrength
• ActiveStatus

How it works

Permanent genomic excision of mutant allele using haplotype-specific PAM-altering SNPs achieves selective mutant huntingtin suppression without affecting the normal allele

The evidence

• 1Backing articles
• 1Publishers
• 1Evidence records
• Sep 2016–Sep 2016Coverage

• Illustration H

  Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9

  Human Molecular Genetics · Sep 15, 2016 High trust

  Backs 4 claims

  • Htt Gene Mutation ✚ Mutant Huntingtin Protein
  • Mutant Huntingtin Protein ⚡ Neurodegeneration
  • Allele Specific Crispr Cas9 ✕ Mutant Huntingtin Protein
  • Allele Specific Crispr Cas9 ✚ Htt Lowering Therapy

  Read article →

Where it sits

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