Thematic Pro

Causal claim

Htt Lowering Therapy ↓ Neurodegeneration

Htt Lowering Therapy decreases Neurodegeneration.

They pull in opposite directions: more cause, less effect. The map scores it at 45% confidence, weighed from 1 article.

• DecreasesRelation
• -Polarity
• 45%Confidence
• weeksLag
• StrongStrength
• ActiveStatus

How it works

RNAi silencing of mutant htt reduces toxic protein, providing therapeutic benefit in HD mice

The evidence

• 1Backing articles
• 1Publishers
• 1Evidence records
• Feb 2009–Feb 2009Coverage

• Illustration M

  Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice

  Molecular Therapy · Feb 24, 2009 High trust

  Backs 4 claims

  • Htt Gene Mutation ⚡ Neurodegeneration
  • Htt Lowering Therapy ↓ Neurodegeneration
  • Htt Lowering Therapy ↑ Motor Coordination
  • Htt Lowering Therapy ↑ Survival

  Read article →

Where it sits

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