Molecular Therapy
Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice
What this article backs
- Htt Gene Mutation Neurodegeneration
- Htt Lowering Therapy Neurodegeneration
- Htt Lowering Therapy Motor Coordination
- Htt Lowering Therapy Survival
- Htt Gene Mutation triggers Neurodegeneration.
- Htt Lowering Therapy decreases Neurodegeneration.
- Htt Lowering Therapy increases Motor Coordination.
- Htt Lowering Therapy increases Survival.
In its own words
HD mice showed significant reductions in wild-type and mutant htt, and demonstrated improved motor coordination and survival
Huntington's disease (HD) is a fatal neurodegenerative disease caused by mutant huntingtin (htt) protein
silencing mutant htt via RNA interference (RNAi) provides therapeutic benefit in HD mice
