Thematic Pro

Causal claim

Htt Gene Mutation ⚡ Mutant Huntingtin Protein

Htt Gene Mutation triggers Mutant Huntingtin Protein.

The two move together: more cause, more effect. The map scores it at 0% confidence, weighed from 2 articles.

• TriggersRelation
• +Polarity
• 0%Confidence
• unknownLag
• StrongStrength
• DecayedStatus

How it works

CAG trinucleotide repeat expansion in HTT produces a mutant huntingtin protein

The evidence

• 2Backing articles
• 2Publishers
• 2Evidence records
• Oct 2011–Jan 2019Coverage

• Illustration O

  Targeting Huntingtin Expression in Patients with Huntington's Disease

  openalex.org · Jan 1, 2019 High trust

  Backs 2 claims

  • Htt Gene Mutation ⚡ Mutant Huntingtin Protein
  • Antisense Oligonucleotide ↓ Mutant Huntingtin Protein

  Read article →
• Illustration M

  Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin

  Molecular Therapy · Oct 4, 2011 High trust

  Backs 5 claims

  • Htt Gene Mutation ⚡ Mutant Huntingtin Protein
  • Mutant Huntingtin Protein ⚡ Neurodegeneration
  • Antisense Oligonucleotide ↓ Mutant Huntingtin Protein
  • Wild Type Huntingtin Protein ✚ Neurodegeneration
  • Cet Modification ↑ Antisense Oligonucleotide

  Read article →

Where it sits

See it on the live map →