Thematic Pro

Causal claim

Cet Modification ↑ Antisense Oligonucleotide

Cet Modification increases Antisense Oligonucleotide.

The two move together: more cause, more effect. The map scores it at 44% confidence, weighed from 1 article.

• IncreasesRelation
• +Polarity
• 44%Confidence
• unknownLag
• StrongStrength
• ActiveStatus

How it works

S-constrained-ethyl motifs on ASOs significantly improve potency while maintaining allele selectivity in vitro

The evidence

• 1Backing articles
• 1Publishers
• 1Evidence records
• Oct 2011–Oct 2011Coverage

• Illustration M

  Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin

  Molecular Therapy · Oct 4, 2011 High trust

  Backs 5 claims

  • Htt Gene Mutation ⚡ Mutant Huntingtin Protein
  • Mutant Huntingtin Protein ⚡ Neurodegeneration
  • Antisense Oligonucleotide ↓ Mutant Huntingtin Protein
  • Wild Type Huntingtin Protein ✚ Neurodegeneration
  • Cet Modification ↑ Antisense Oligonucleotide

  Read article →

Where it sits

See it on the live map →