Causal claim
Mutant Huntingtin Protein NeurodegenerationMutant Huntingtin Protein triggers Neurodegeneration.
The two move together: more cause, more effect. The map scores it at 29% confidence, weighed from 2 articles.
- TriggersRelation
- +Polarity
- 29%Confidence
- monthsLag
- StrongStrength
- ActiveStatus
How it works
mutant huntingtin aggregates accumulate in brain tissue, driving progressive neuronal dysfunction in zQ175 mice
The evidence
Where it sits
What feeds it
- Antisense Oligonucleotide decreases Mutant Huntingtin Protein.
- Htt Gene Mutation enables Mutant Huntingtin Protein.
- Sky 0515 decreases Mutant Huntingtin Protein.
- Votoplam decreases Mutant Huntingtin Protein.
- Branaplam decreases Mutant Huntingtin Protein.
- Sky 0515 Dose Level decreases Mutant Huntingtin Protein.