Thematic Pro

Causal claim

Htt Lowering Therapy ↓ Mutant Huntingtin Protein

Htt Lowering Therapy decreases Mutant Huntingtin Protein.

They pull in opposite directions: more cause, less effect. The map scores it at 61% confidence, weighed from 2 articles.

• DecreasesRelation
• -Polarity
• 61%Confidence
• unknownLag
• UnspecifiedStrength
• ActiveStatus

How it works

therapies aimed at lowering mutant huntingtin levels reduce the toxic protein driving neurodegeneration

The evidence

• 2Backing articles
• 2Publishers
• 2Evidence records
• Jul 2015–Aug 2017Coverage

• Illustration E

  Huntington's disease: a clinical review

  European Journal of Neurology · Aug 17, 2017 High trust

  Backs 4 claims

  • Htt Gene Mutation ✚ Mutant Huntingtin Protein
  • Mutant Huntingtin Protein ⚡ Neurodegeneration
  • Htt Lowering Therapy ↓ Mutant Huntingtin Protein
  • Antisense Oligonucleotide ↓ Mutant Huntingtin Protein

  Read article →
• S

  Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression - Scientific Reports

  Scientific Reports · Jul 15, 2015 High trust

  Backs 3 claims

  • Htt Gene Mutation ↑ Mutant Huntingtin Protein
  • Neurodegeneration ↔ Mutant Huntingtin Protein
  • Htt Lowering Therapy ↓ Mutant Huntingtin Protein

  Read article →

Where it sits

See it on the live map →