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Development of cognitive, motor, metabolic, and mutant huntingtin aggregation in the zQ175 mouse model of Huntington’s disease - Scientific Reports

Scientific Reports, 2025 · Cited by 3 papers · doi:10.1038/s41598-025-17956-5

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What this article backs

• Mutant Huntingtin Protein ⚡ Neurodegeneration
• Htt Gene Mutation ✚ Mutant Huntingtin Protein

• Mutant Huntingtin Protein triggers Neurodegeneration.
• Htt Gene Mutation enables Mutant Huntingtin Protein.

In its own words

Development of cognitive, motor, metabolic, and mutant huntingtin aggregation in the zQ175 mouse model of Huntington's disease

mutant huntingtin aggregation in the zQ175 mouse model of Huntington's disease

Corroborated by

• S

  Toxic Clumps in Huntington's Disease May Protect the Brain Too

  singularityhub.com · Jun 5, 2026 Standard

  Backs 2 claims

  • Mutant Huntingtin Protein ⚡ Neurodegeneration
  • Mutant Huntingtin Protein Aggregates ✕ Neurodegeneration

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• S

  Scientists Are Finally Closing In on a Treatment For Huntington's Disease

  sciencealert.com · Jan 15, 2026 Standard

  Backs 1 claim

  • Htt Gene Mutation ✚ Mutant Huntingtin Protein

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• H

  Huntington’s: Huntingtin protein function loss plays key role

  huntingtonsdiseasenews.com · Jul 22, 2025 Standard

  Backs 1 claim

  • Htt Gene Mutation ✚ Mutant Huntingtin Protein

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• Illustration N

  Targeting Huntingtin Expression in Patients with Huntington’s Disease

  New England Journal of Medicine · May 7, 2019 High trust

  Backs 2 claims

  • Htt Gene Mutation ✚ Mutant Huntingtin Protein
  • Antisense Oligonucleotide ↓ Mutant Huntingtin Protein

  Read article →
• Illustration E

  Huntington's disease: a clinical review

  European Journal of Neurology · Aug 17, 2017 High trust

  Backs 4 claims

  • Htt Gene Mutation ✚ Mutant Huntingtin Protein
  • Mutant Huntingtin Protein ⚡ Neurodegeneration
  • Htt Lowering Therapy ↓ Mutant Huntingtin Protein
  • Antisense Oligonucleotide ↓ Mutant Huntingtin Protein

  Read article →
• Illustration H

  Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9

  Human Molecular Genetics · Sep 15, 2016 High trust

  Backs 4 claims

  • Htt Gene Mutation ✚ Mutant Huntingtin Protein
  • Mutant Huntingtin Protein ⚡ Neurodegeneration
  • Allele Specific Crispr Cas9 ✕ Mutant Huntingtin Protein
  • Allele Specific Crispr Cas9 ✚ Htt Lowering Therapy

  Read article →

More from Nature

• N

  Huntington’s disease treated for first time using gene therapy

  Nature · Sep 25, 2025 Standard

  Backs 1 claim

  • Gene Therapy ↓ Mutant Huntingtin Protein

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