Causal claim
Htt Lowering Therapy Neurofilament LightHtt Lowering Therapy decreases Neurofilament Light.
They pull in opposite directions: more cause, less effect. The map scores it at 42% confidence, weighed from 1 article.
- DecreasesRelation
- -Polarity
- 42%Confidence
- monthsLag
- ModerateStrength
- ActiveStatus
How it works
Lowering mutant huntingtin in the brain slows neuronal injury, which stabilises and reduces elevated NfL, making NfL a pharmacodynamic response biomarker
The evidence
Where it sits
What feeds it
What it drives
Nothing downstream on the map yet.