Causal claim
Msh3 Lowering Therapy Somatic Cag ExpansionMsh3 Lowering Therapy decreases Somatic Cag Expansion.
They pull in opposite directions: more cause, less effect. The map scores it at 42% confidence, weighed from 1 article.
- DecreasesRelation
- -Polarity
- 42%Confidence
- chronicLag
- ModerateStrength
- ActiveStatus
How it works
Di-valent siRNA lowers MSH3 in the brain, which blocks the mismatch-repair-driven somatic expansion of the CAG repeat
The evidence
Where it sits
What feeds it
Nothing upstream on the map yet.