ncbi.nlm.nih.gov
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment - PMC
What this article backs
In its own words
A proposed cyclical process suggests that increased dopaminergic transmission in mania leads to secondary down-regulation of dopaminergic receptor sensitivity over time, potentially leading to decreased dopaminergic transmission corresponding with the depressive phase.
Converging findings from pharmacological and imaging studies support the hypothesis that a state of hyperdopaminergia, specifically elevations in D2/3 receptor availability and a hyperactive reward processing network, underlies mania.