Dopamine Dysregulation increases Manic Episode.

The two move together: more cause, more effect. The map scores it at 53% confidence, weighed from 2 articles.

IncreasesRelation
+Polarity
53%Confidence
variesLag
ModerateStrength
ActiveStatus

How it works

Converging imaging and pharmacological evidence ties mania to hyperdopaminergia - elevated D2/3 receptor availability and hyperactive reward circuitry - and dopamine-boosting drugs can induce mania.

The evidence

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov High trust
Backs 1 claim
- Dopamine Dysregulation Manic Episode
Read article →
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment - PMC

ncbi.nlm.nih.gov High trust
Backs 2 claims
- Dopamine Dysregulation Manic Episode
- Manic Episode Depressive Episode
Read article →

Where it sits

What feeds it

Substance Use increases Dopamine Dysregulation.

What it drives

Manic Episode increases Clang Associations.
Manic Episode correlates with Mixed Episode.
Manic Episode increases Psychosis Risk.
Manic Episode increases Functional Impairment.
Manic Episode decreases Cognitive Performance.
Manic Episode triggers Depressive Episode.

See it on the live map →