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Altered dopamine signaling is hypothesized to contribute to bipolar disorder symptoms, as D2-antagonists reduce mania symptoms while drugs that activate dopamine receptors or increase dopamine release can induce mania.
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment - PMC
ncbi.nlm.nih.gov High trust
Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis - PubMed
pubmed.ncbi.nlm.nih.gov High trust