Manic Episode triggers Depressive Episode.

The two move together: more cause, more effect. The map scores it at 30% confidence, weighed from 1 article.

TriggersRelation
+Polarity
30%Confidence
variesLag
UnspecifiedStrength
ActiveStatus

How it works

A proposed cyclical model: sustained dopaminergic excess in mania drives compensatory receptor down-regulation that tips the system into the subsequent depressive phase.

The evidence

The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment - PMC

ncbi.nlm.nih.gov High trust
Backs 2 claims
- Dopamine Dysregulation Manic Episode
- Manic Episode Depressive Episode
Read article →

Where it sits

What feeds it

Lithium Treatment decreases Manic Episode.
Antipsychotic Treatment decreases Manic Episode.
Dopamine Dysregulation increases Manic Episode.
Circadian Rhythm Disruption triggers Manic Episode.
Sleep Deprivation triggers Manic Episode.
Trauma-Focused Psychotherapy decreases Manic Episode.

What it drives

Depressive Episode triggers Hypomanic Episode.
Depressive Episode correlates with Mixed Episode.
Depressive Episode enables Residual Depressive Symptoms.
Depressive Episode enables Misdiagnosis.
Depressive Episode decreases Cognitive Performance.
Depressive Episode triggers Negativity Bias.

See it on the live map →